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The University of Louisville (UofL) is a public research university in Louisville, Kentucky. It is part of the Kentucky state university system. When founded in 1798, it was one of the first city-owned public colleges in the United States and one of the first universities chartered west of the Allegheny Mountains.[citation needed] The university is mandated by the Kentucky General Assembly to be a “Preeminent Metropolitan Research University”. It enrolls students from 118 of 120 Kentucky counties, all 50 U.S. states, and 116 countries around the world.

Louisville is classified among “R1: Doctoral Universities – Very high research activity”. The University of Louisville School of Medicine is touted for the first fully self-contained artificial heart transplant surgery, as well as the first successful hand transplantation in the United States. The University Hospital is also credited with the first civilian ambulance, the nation’s first accident services, now known as an emergency department (ED), and one of the first blood banks in the US.

University of Louisville is known for the Louisville Cardinals athletics programs. Since 2005, the Cardinals have made appearances in the NCAA Division I men’s basketball Final Four in 2005, 2012, and 2013 (vacated), football Bowl Championship Series Orange Bowl in 2007 (champions) and Sugar Bowl in 2013 (champions), the College Baseball World Series 2007, 2013, 2014, 2017 and 2019, the women’s basketball Final Four in 2009 (runner-up), 2013 (runner-up), and 2018, and the men’s soccer national championship game in 2010.[16] The Louisville Cardinals Women’s Volleyball program has three-peated as champions of the Big East Tournament (2008, 2009, 2010), and were Atlantic Coast Conference Champions in 2015 and 2017. Women’s track and field program has won Outdoor Big East titles in 2008, 2009 and 2010 and an Indoor Big East title in 2011.
The University of Louisville traces its roots to a charter granted in 1798[17] by the Kentucky General Assembly to establish a school of higher learning in the newly founded town of Louisville. It ordered the sale of 6,000 acres (24 km2) of South Central Kentucky land to underwrite construction, joined on April 3, 1798, by eight community leaders who began local fund raising for what was then known as the Jefferson Seminary. It opened 15 years later and offered college and high school level courses in a variety of subjects. It was headed by Edward Mann Butler from 1813 to 1816, who later ran the first public school in Kentucky in 1829 and is considered Kentucky’s first historian.

Despite the Jefferson Seminary’s early success, pressure from newly established public schools and media critiques of it as “elitist” would force its closure in 1829.

Eight years later, in 1837, the Louisville City council established the Louisville Medical Institute at the urging of renowned physician and medical author Charles Caldwell. As he had earlier at Lexington’s Transylvania University, Caldwell rapidly led LMI into becoming one of the leading medical schools west of the Allegheny Mountains. In 1840, Louisville College, a rival medical school chartered a few years earlier as the Louisville Collegiate Institute, was established after an LMI faculty dispute. It opened in 1844 on land near the present day Health sciences campus.